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aerobics can lift depression WESTPORT, CT (Reuters Health) Apr 05 - A simple program of regular aerobic exercise can substantially improve depression scores in patients with moderate to severe major depression, despite prior failures with pharmacologic therapy. The new findings provide "grounds for cautious optimism" about the use of exercise therapy as an alternative treatment for depression, Dr. F. Dimeo, of the Benjamin Franklin Medical Center, in Berlin, Germany, and colleagues conclude in the April issue of the British Journal of Sports Medicine. The investigators studied the effects of aerobic exercise on depression in 12 patients with major depressive episodes ranging from 12 to 96 weeks in duration. Of the patients, 10 were characterized as having refractory depression after failing to improve during treatment with at least two different classes of antidepressants for at least 4 weeks during the current episode. The intervention consisted of interval training (walking speed) on a treadmill for 30 minutes a day for 10 days. Overall, exercise training caused a clinically significant drop in depression scores during the 10 days. Of the twelve patients in the study, six demonstrated "substantial" improvements &Mac247; including five of the patients with refractory depression &Mac247; two demonstrated slight improvements and four remained unchanged. Moreover, there was a high rate of acceptance of the intervention among the group, Dr. Dimeo told Reuters Health. "Indeed, several patients asked to continue the training program after the study was concluded." The study director added that many questions remain about the role that aerobic exercise should play in the treatment of depression. "Aerobic exercise may certainly be used as complementary therapy in severely depressed patients who receive antidepressants and do not have contraindications for exercise. Since there is no evidence about the long-term effects of exercise [and] compliance and outcomes when stopping training, aerobic exercise should not be used as first-line therapy for depression until confirmatory studies have been concluded." Dr. Dimeo noted that the team has already initiated a larger, randomized trial of aerobic exercise in depression. Preliminary results from this study, he said, "are very promising." Br J Sports Med 2001;35:114-117. COMMON SENSE |
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